Large Mammal BPF Prize Winning Announcement
A technology designed to preserve synapses across the whole brain of a large mammal is successful Using a combination of ultrafast glutaraldehyde fixation and very low temperature storage, [...]
Nerve transfers as a window into the capacity for human sensory adaptation
Let’s imagine that in a hypothetical future world, head transplants become possible, as somehow the massive technical challenge of reattaching the brain to the spinal cord can be overcome. [...]
Simulating motion detection in the Drosophila visual system with connectome data
A new manuscript from Gornet et al. describes their work using a serial electron micrograph-derived Drosophila connectome to simulate motion-detection in neurons in the T4 area of the optic lobe: [...]
Single cell gene expression with or without cryopreservation
In cryobiology, it is generally thought that cellular gene expression profiles do not change substantially following cryopreservation. This is important because if viability cannot be directly [...]
New options to rewarm tissue from the vitreous state
A manuscript by Manuchehrabadi et al. about using magnetic nanoparticles to improve rewarming of vitrified tissue samples made quite a splash when it was published earlier this month. What is the [...]
How computational researchers can contribute to brain preservation research
It is sometimes claimed that it is impossible for people without strong wet-lab skills in biology and/or neuroscience to personally contribute to research associated with brain preservation. As [...]
Interest in cryonics from the Less Wrong 2016 survey
The Less Wrong (LW) extended community — an internet community interested in the application of rational thinking — recently conducted a survey of their members, thanks in part to the [...]
How much protein structure loss is there following glutaraldehyde crosslinking?
One of the key questions that I’ve had following the publication and success of aldehyde stabilized cryopreservation at mouse brain preservation is the degree to which the glutaraldehyde [...]
Small Mammal Announcement Redirect
Oops! We used the wrong link. Please go here for the full announcement.
The preservation of extracellular space in the brain
Although most people usually focus on the brain cells when discussing brain preservation techniques, extracellular space is also worthy of consideration. In vivo, extracellular space makes up [...]
